Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Synonyms [1]
PI3K-C2GAMMA, PI3K-C2-gamma

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma (PIK3C2G) is a gene that encodes a protein that is a member of the phosphoinositide 3-kinase family. The protein is involved in cell signaling pathways that regulate cell proliferation, onogenic transformation, cell survival, cell migration, and intracellular protein trafficking. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as cancers of the biliary tract, intestinal cancer, and skin cancer.

PIK3C2G is altered in 3.00% of all cancers with lung adenocarcinoma, cutaneous melanoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

PIK3C2G GENIE Cases - Top Diseases

The most common alterations in PIK3C2G are PIK3C2G Mutation (2.05%), PIK3C2G Amplification (0.57%), PIK3C2G Loss (0.11%), PIK3C2G R738C (0.04%), and PIK3C2G E1394K (0.03%) [3].

PIK3C2G GENIE Cases - Top Alterations

Significance of PIK3C2G in Diseases

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.