Location [1]
Protein [2]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Synonyms [1]

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta (PIK3CB) is a gene that encodes a protein that is the catalytic subunit of PIK3B, a complex involved in the activation pathway of neutorphils. Missense mutations, silent mutations, nonsense mutations, frameshift deletions, and frameshift insertions are observed in cancers such as skin cancer, endometrial cancer, and colon cancer.

PIK3CB is altered in 1.62% of all cancers with colon adenocarcinoma, prostate adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

PIK3CB GENIE Cases - Top Diseases

The most common alterations in PIK3CB are PIK3CB Mutation (1.16%), PIK3CB Amplification (0.30%), PIK3CB E1051K (0.05%), PIK3CB R321Q (0.04%), and PIK3CB D1067V (0.04%) [3].

PIK3CB GENIE Cases - Top Alterations

Significance of PIK3CB in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Melanoma +

Squamous Cell Lung Carcinoma +

Bladder Carcinoma +

Colorectal Carcinoma +

Glioblastoma +

Head And Neck Carcinoma +

Prostate Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Ovarian Carcinoma +

Anaplastic Astrocytoma +

Non-Small Cell Lung Carcinoma +

Pancreatic Carcinoma +

Sarcoma +

Lymphoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.