Overview

Location [1]
7q22.3
Pathway
PI3K/AKT1/MTOR
Protein [2]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Synonyms [1]
p120-PI3K, PI3CG, PIK3, PI3K, p110gamma, PI3Kgamma

Phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit gamma (PIK3CG) is a gene that encodes a protein that is a member of the pi3/pi4-kinase family. The protein functions in the phosphorylation of inositol rings and the association of adheren junctions. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

PIK3CG is altered in 2.42% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, breast invasive ductal carcinoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].

PIK3CG GENIE Cases - Top Diseases

The most common alterations in PIK3CG are PIK3CG Mutation (1.69%), PIK3CG Mutation (somatic) (1.69%), PIK3CG Amplification (0.11%), PIK3CG Loss (0.03%), and PIK3CG E615K (0.02%) [3].

PIK3CG GENIE Cases - Top Alterations

Significance of PIK3CG in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Hodgkin Lymphoma +

Squamous Cell Lung Carcinoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Melanoma +

Glioblastoma +

Endometrial Carcinoma +

Cancer +

Renal Cell Carcinoma +

Gastric Adenocarcinoma +

Prostate Carcinoma +

Pancreatic Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Hematopoietic And Lymphoid Malignancy +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Ovarian Carcinoma +

Peritoneal Mesothelioma +

Thyroid Gland Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.