Biomarkers /
PIK3CG
Overview
Phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit gamma (PIK3CG) is a gene that encodes a protein that is a member of the pi3/pi4-kinase family. The protein functions in the phosphorylation of inositol rings and the association of adheren junctions. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.
Clinical Trials
Significance of PIK3CG in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.