Overview

Location [1]
7q22.3
Pathway
PI3K/AKT1/MTOR
Synonyms [1]
PI3K, PI3Kgamma, PIK3, p110gamma, PI3CG, p120-PI3K

Phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit gamma (PIK3CG) is a gene that encodes a protein that is a member of the pi3/pi4-kinase family. The protein functions in the phosphorylation of inositol rings and the association of adheren junctions. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

Significance of PIK3CG in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Non-Small Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Hepatocellular Carcinoma +

Melanoma +

Renal Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Aggressive Systemic Mastocytosis +

Cancer +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Endometrial Carcinoma +

Ewing Sarcoma +

Gastric Adenocarcinoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Liposarcoma +

Mast Cell Leukemia +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Osteosarcoma +

Ovarian Carcinoma +

Pecoma +

Pancreatic Carcinoma +

Peritoneal Mesothelioma +

Prostate Carcinoma +

Small Cell Lung Carcinoma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thyroid Gland Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.