Overview

Location [1]
7q22.3
Pathway
PI3K/AKT1/MTOR
Protein [2]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Synonyms [1]
PI3Kgamma, p120-PI3K, PI3CG, PIK3, p110gamma, PI3K

Phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit gamma (PIK3CG) is a gene that encodes a protein that is a member of the pi3/pi4-kinase family. The protein functions in the phosphorylation of inositol rings and the association of adheren junctions. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

PIK3CG is altered in 2.42% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, breast invasive ductal carcinoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].

PIK3CG GENIE Cases - Top Diseases

The most common alterations in PIK3CG are PIK3CG Mutation (1.69%), PIK3CG Amplification (0.11%), PIK3CG Loss (0.03%), PIK3CG E615K (0.02%), and PIK3CG R477H (0.02%) [3].

PIK3CG GENIE Cases - Top Alterations

Significance of PIK3CG in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Melanoma +

Squamous Cell Lung Carcinoma +

Renal Cell Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Hepatocellular Carcinoma +

Small Cell Lung Carcinoma +

Glioblastoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Cancer +

Gastric Adenocarcinoma +

Prostate Carcinoma +

Pancreatic Carcinoma +

Aggressive Systemic Mastocytosis +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Ewing Sarcoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Liposarcoma +

Mast Cell Leukemia +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Osteosarcoma +

Ovarian Carcinoma +

Pecoma +

Peritoneal Mesothelioma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thyroid Gland Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.