Overview

Location [1]
19p13.11
Pathway
PI3K/AKT1/MTOR
Protein [2]
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms [1]
p85, MPPH1, p85-BETA, P85B, MPPH

Phosphoinositide-3-kinase, regulatory subunit 2 (beta) (PIK3R2) is a gene that encodes a lipid kinase that functions in growth signaling pathways by producing second messengers. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

PIK3R2 is altered in 1.40% of all cancers with breast carcinoma, non-small cell lung carcinoma, uterine corpus neoplasm, colorectal adenocarcinoma, and melanoma having the greatest prevalence of alterations [3].

PIK3R2 GENIE Cases - Top Diseases

The most common alterations in PIK3R2 are PIK3R2 Mutation (0.66%), PIK3R2 Mutation (somatic) (0.66%), PIK3R2 Amplification (0.15%), PIK3R2 G373R (0.03%), and PIK3R2 D557Y (0.01%) [3].

PIK3R2 GENIE Cases - Top Alterations

Significance of PIK3R2 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Endometrial Carcinoma +

Non-Hodgkin Lymphoma +

Squamous Cell Lung Carcinoma +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Glioblastoma +

Melanoma +

Colorectal Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Prostate Carcinoma +

Thyroid Gland Carcinoma +

Gastric Adenocarcinoma +

Pancreatic Carcinoma +

Renal Cell Carcinoma +

Cancer +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Peritoneal Mesothelioma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.