Biomarkers /
PIK3R2
Overview
Phosphoinositide-3-kinase, regulatory subunit 2 (beta) (PIK3R2) is a gene that encodes a lipid kinase that functions in growth signaling pathways by producing second messengers. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.
PIK3R2 is altered in 1.29% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].
The most common alterations in PIK3R2 are PIK3R2 Mutation (1.09%), PIK3R2 Amplification (0.29%), PIK3R2 G373R (0.07%), PIK3R2 E189A (2.20%), and PIK3R2 Loss (0.05%) [3].
Clinical Trials
Significance of PIK3R2 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.