Associated Genetic Biomarkers
Phosphoinositide-3-kinase, regulatory subunit 5 (PIK3R5) is a gene that encodes a protein that plays an important role in cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking. Missense mutations, silent mutations, and nonsense mutations are observed in cancers such as skin cancer, colon cancer, and endometrial cancer.
PIK3R5 status serves as an inclusion eligibility criteria in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial that contains PIK3R5 status as an inclusion criterion, 1 is phase 2 (0 open).
Significance of PIK3R5 in Diseases
Head And Neck Squamous Cell Carcinoma +
PIK3R5 is an inclusion criterion in 1 clinical trial for head and neck squamous cell carcinoma, of which 0 are open and 1 is closed. Of the trial that contains PIK3R5 status and head and neck squamous cell carcinoma as inclusion criteria, 1 is phase 2 (0 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.