Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Phosphoinositide 3-kinase regulatory subunit 5
Synonyms [1]
F730038I15Rik, FOAP-2, p101, P101-PI3K

Phosphoinositide-3-kinase, regulatory subunit 5 (PIK3R5) is a gene that encodes a protein that plays an important role in cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking. Missense mutations, silent mutations, and nonsense mutations are observed in cancers such as skin cancer, colon cancer, and endometrial cancer.

Significance of PIK3R5 in Diseases

Head And Neck Squamous Cell Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.