Overview

Location [1]
6p21.2
Protein [2]
Serine/threonine-protein kinase pim-1
Synonyms [1]
PIM

Pim-1 proto-oncogene, serine/threonine kinase (PIM1) is a gene that encodes a protein that functions as a serine/threonine kinase. The protein perpetuates signal transduction in blood cells and contributes to cell proliferation and survival. Fusions, missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as hematopoietic and lymphoid cancers, intestinal cancer, and skin cancer.

PIM1 is altered in 0.84% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, lung adenocarcinoma, colon adenocarcinoma, follicular lymphoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

PIM1 GENIE Cases - Top Diseases

The most common alterations in PIM1 are PIM1 Mutation (0.56%), PIM1 Amplification (0.23%), PIM1 S97N (0.05%), PIM1 G28D (0.05%), and PIM1 Loss (0.03%) [3].

PIM1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.