Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Synonyms [1]

PLCB4 is altered in 0.47% of all cancers.

The most common alterations in PLCB4 are PLCB4 Mutation (0.02%), PLCB4 A185T (0.00%), PLCB4 A265T (0.00%), PLCB4 K1012E (0.00%), and PLCB4 L17Cfs*32 (0.00%) [3].

PLCB4 GENIE Cases - Top Alterations

Significance of PLCB4 in Diseases

Melanoma +

Uveal Melanoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.