PLCG2
Phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2) is a gene that encodes a protein that functions as a transmembrane signaling enzyme. The protein is important in the catalytic conversion of 1-phosphatidyl-1D-myo-inositol 4, 5-bisphosphate to 1D-myo-inostiol 1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG). These products transmit signals from growth factor receptors and immune system receptors. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and parathyroid cancer.