Biomarkers /

PLK2

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Overview

Location [1]
5q11.2
Protein [2]
Serine/threonine-protein kinase PLK2
Synonyms [1]
hPlk2, hSNK, SNK

PLK2 is altered in 1.27% of all cancers with prostate adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, lung adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

PLK2 GENIE Cases - Top Diseases

The most common alterations in PLK2 are PLK2 Loss (0.24%), PLK2 Amplification (0.08%), PLK2 F363L (0.01%), PLK2 R672* (0.01%), and PLK2 X576_splice (0.02%) [3].

PLK2 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.