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PMAIP1

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Associated Diseases

Overview

Location [1]
18q21.32
Protein [2]
Phorbol-12-myristate-13-acetate-induced protein 1
Synonyms [1]
NOXA, APR

PMAIP1 is altered in 0.47% of all cancers with colon adenocarcinoma, lung adenocarcinoma, prostate adenocarcinoma, breast invasive ductal carcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

PMAIP1 GENIE Cases - Top Diseases

The most common alterations in PMAIP1 are PMAIP1 Loss (0.32%), PMAIP1 Amplification (0.06%), PMAIP1 X20_splice (0.01%), PMAIP1 L43* (0.01%), and PMAIP1 E20* (0.01%) [3].

PMAIP1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.