Promyelocytic leukemia (PML), is a gene that encodes for a transcription factor and tumor suppressor protein (Gene 2013a). PML is involved in rearrangements observed in AML, particularly APL (acute promyelocytic leukemia).
Retinoic acid receptor, alpha (RARA) is a gene that encodes for a nuclear retinoic acid receptor, a transcription regulating protein (Gene 2013b). In cancer, rearrangements involving RARA have been observed in AML and APL. Its role is also being investigated in gastric and other cancers.
The PML-RARA fusion has been observed in most cases of APL.