Promyelocytic leukemia (PML) is a gene that encodes a protein that functions as a transcription factor and tumor repressor in nuclear bodies. The protein also regulates the p53 response to oncogenic signals. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as bone cancer, intestinal cancer, and stomach cancer.
Modified: July 1, 2015
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