Overview

Location [1]
15q24.1
Protein [2]
Protein PML
Synonyms [1]
MYL, PP8675, TRIM19, RNF71

Promyelocytic leukemia (PML) is a gene that encodes a protein that functions as a transcription factor and tumor repressor in nuclear bodies. The protein also regulates the p53 response to oncogenic signals. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as bone cancer, intestinal cancer, and stomach cancer.

PML is altered in 0.01% of all cancers.

The most common alteration in PML is PML Loss (0.00%) [3].

PML GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of PML in Diseases

Acute Promyelocytic Leukemia +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Chronic Lymphocytic Leukemia +

Chronic Myelomonocytic Leukemia +

Refractory Anemia With Excess Blasts +

Acute Lymphoblastic Leukemia +

Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative +

Mantle Cell Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm +

Myeloid Sarcoma +

Myeloproliferative Neoplasm +

Refractory Anemia With Excess Blasts-1 +

Refractory Anemia With Excess Blasts-2 +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.