Biomarkers /

PNRC1

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Overview

Location [1]
6q15
Protein [2]
Proline-rich nuclear receptor coactivator 1
Synonyms [1]
PROL2, B4-2, PRR2, PNAS-145

PNRC1 is altered in 0.63% of all cancers with prostate adenocarcinoma, lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

PNRC1 GENIE Cases - Top Diseases

The most common alterations in PNRC1 are PNRC1 Loss (0.14%), PNRC1 Amplification (0.03%), PNRC1 K101del (0.02%), PNRC1 R73G (0.01%), and PNRC1 V140_L147del (0.06%) [3].

PNRC1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.