Location [1]
Protein [2]
DNA polymerase theta
Synonyms [1]

POLQ is altered in 5.87% of all cancers with lung adenocarcinoma, colon adenocarcinoma, melanoma, breast invasive ductal carcinoma, and glioblastoma having the greatest prevalence of alterations [3].

POLQ GENIE Cases - Top Diseases

The most common alterations in POLQ are POLQ Mutation (5.65%), POLQ Fusion (0.16%), POLQ L1430fs (0.09%), POLQ C2411S (0.06%), and POLQ M307V (0.07%) [3].

POLQ GENIE Cases - Top Alterations

Significance of POLQ in Diseases

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma +

Urothelial Carcinoma +

Malignant Solid Tumor +

Mantle Cell Lymphoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.