Overview

Location [1]
2p23.2
Protein [2]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Synonyms [1]
PPP1CD, NSLH2, PPP1beta, PP1c, PP1B, PP1beta, MP, HEL-S-80p, PP-1B

Protein phosphatase 1, catalytic subunit, beta isozyme (PPP1CB) is a gene that encodes a protein that functions as a catalytic subunit of protein phosphatase 1 (PP1). PP1 regulates cellular processes such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Fusions, missense mutations, nonsense mutations, silent mutations, nonstop extensions, and frameshift insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

PPP1CB is altered in 0.09% of all cancers with lung adenocarcinoma, glioblastoma, acute myeloid leukemia, cancer of unknown primary, and diffuse large B-cell lymphoma, not otherwise specified having the greatest prevalence of alterations [3].

PPP1CB GENIE Cases - Top Diseases

The most common alteration in PPP1CB is PPP1CB-ALK Fusion (0.09%) [3].

PPP1CB GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.