Overview

Location [1]
8q13.2
Protein [2]
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
Synonyms [1]
DEPDC2, DEP.2, P-REX2, PPP1R129

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (PREX2) is a gene that encodes a protein that functions as a RAC1 guanine nucleotide exchange factor. Missense mutations, synonymous mutations, nonsense mutations, frameshift deletions, and frameshift insertions are observed in cancers such as colon cancer, esophageal cancer, and lung cancer.

PREX2 is altered in 5.43% of all cancers with cutaneous melanoma, lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

PREX2 GENIE Cases - Top Diseases

The most common alterations in PREX2 are PREX2 Amplification (1.47%), PREX2 R297C (0.04%), PREX2 G164E (0.03%), PREX2 Loss (0.03%), and PREX2 R1149C (0.03%) [3].

PREX2 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.