Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
cAMP-dependent protein kinase catalytic subunit alpha
Synonyms [1]

PRKACA is altered in 0.13% of all cancers with fibrolamellar carcinoma, hepatocellular carcinoma, conventional glioblastoma multiforme, pancreatic adenocarcinoma, and adenocarcinoma of unknown primary having the greatest prevalence of alterations [3].

PRKACA GENIE Cases - Top Diseases

The most common alterations in PRKACA are PRKACA-DNAJB1 Fusion (0.03%), PRKACA A224V (0.09%), PRKACA A233V (0.07%), PRKACA A35T (0.07%), and PRKACA E108V (0.07%) [3].

PRKACA GENIE Cases - Top Alterations

Significance of PRKACA in Diseases

Fibrolamellar Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.