Location [1]
Protein [2]
cAMP-dependent protein kinase type I-alpha regulatory subunit
Synonyms [1]

Protein kinase, cAMP-dependent, regulatory, type I, alpha (PRKAR1A) is a gene that encodes a protein that functions as a regulatory subunit of cAMP-dependent protein kinase. The protein is also a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as adrenal cancer, soft tissue cancer, and testicular cancer.

PRKAR1A is altered in 1.06% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, invasive breast carcinoma, colon adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

PRKAR1A GENIE Cases - Top Diseases

The most common alterations in PRKAR1A are PRKAR1A Amplification (0.60%), PRKAR1A-ALK Fusion (0.09%), PRKAR1A Loss (0.04%), PRKAR1A R13H (0.02%), and PRKAR1A S155L (0.02%) [3].

PRKAR1A GENIE Cases - Top Alterations

Significance of PRKAR1A in Diseases

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Malignant Solid Tumor +

Thyroid Gland Papillary Carcinoma +

Lymphoma +

Histiocytosis +

Thyroid Gland Medullary Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.