Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Protein kinase C alpha type
Synonyms [1]
AAG6, PKCalpha, PKCA, PKC-alpha, PRKACA, PKCI+/-

PRKCA is altered in 0.09% of all cancers with cutaneous melanoma, conventional glioblastoma multiforme, breast invasive ductal carcinoma, gliosarcoma, and melanoma having the greatest prevalence of alterations [3].

PRKCA GENIE Cases - Top Diseases

The most common alterations in PRKCA are PRKCA Mutation (1.18%), PRKCA Fusion (0.01%), PRKCA V526I (0.18%), PRKCA-MAP3K14 Fusion (0.01%), and PRKCA A2T (0.07%) [3].

PRKCA GENIE Cases - Top Alterations

Significance of PRKCA in Diseases

Cutaneous Melanoma +

Malignant Solid Tumor +

Colorectal Carcinoma +

Uveal Melanoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.