Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Protein kinase C epsilon type
Synonyms [1]
nPKC-epsilon, PKCE

PRKCE is altered in 0.16% of all cancers with breast invasive ductal carcinoma, breast invasive lobular carcinoma, breast neoplasm, lung adenocarcinoma, and mixed lobular and ductal breast carcinoma having the greatest prevalence of alterations [3].

PRKCE GENIE Cases - Top Diseases

The most common alterations in PRKCE are PRKCE Amplification (0.91%), PRKCE Loss (0.12%), PRKCE D431H (0.04%), PRKCE D505N (0.04%), and PRKCE D541E (0.04%) [3].

PRKCE GENIE Cases - Top Alterations

Significance of PRKCE in Diseases

Malignant Solid Tumor +

Colorectal Carcinoma +

Cutaneous Melanoma +

Uveal Melanoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.