Overview

Location [1]
1q31.1
Protein [2]
Prostaglandin G/H synthase 2
Synonyms [1]
GRIPGHS, hCox-2, COX2, PHS-2, PGHS-2, PGG/HS, COX-2

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2) is a gene that encodes a protein that is the key enzyme in prostaglandin biosynthesis. Missense mutations, silent mutations, and nonsense mutations are observed in cancers such as skin cancer, colon cancer, and endometrial cancer.

PTGS2 is altered in 1.17% of all cancers with high grade ovarian serous adenocarcinoma, anaplastic astrocytoma, bladder urothelial carcinoma, cervical mucinous adenocarcinoma, gastric type, and colon adenocarcinoma having the greatest prevalence of alterations [3].

PTGS2 GENIE Cases - Top Diseases

The most common alterations in PTGS2 are PTGS2 D483N (0.28%), PTGS2 C42* (0.22%), PTGS2 D300N (0.39%), PTGS2 E165G (0.22%), and PTGS2 G153S (0.22%) [3].

PTGS2 GENIE Cases - Top Alterations

Significance of PTGS2 in Diseases

Breast Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.