Overview

Location [1]
6p21.1
Protein [2]
Inactive tyrosine-protein kinase 7
Synonyms [1]
CCK-4, CCK4

Protein tyrosine kinase 7 (inactive) (PTK7) is a gene that encodes a receptor protein tyrosine kinase that does not have catalytic tyrosine kinase activity. The protein functions in the Wnt signaling pathway and cell processes such as polarity and adhesion. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Significance of PTK7 in Diseases

Non-Small Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.