Location [1]
Protein [2]
Tyrosine-protein phosphatase non-receptor type 1
Synonyms [1]

PTPN1 is altered in 0.16% of all cancers with conventional glioblastoma multiforme, acute myeloid leukemia, diffuse large B-cell lymphoma, not otherwise specified, chronic myeloid leukemia, and colorectal adenocarcinoma having the greatest prevalence of alterations [3].

PTPN1 GENIE Cases - Top Diseases

The most common alterations in PTPN1 are PTPN1 Loss (0.45%), PTPN1 A69T (0.08%), PTPN1 A122T (0.07%), PTPN1 A35T (0.02%), and PTPN1 Amplification (0.02%) [3].

PTPN1 GENIE Cases - Top Alterations

Significance of PTPN1 in Diseases

Diffuse Glioma +

Astrocytic Tumor +

Dysembryoplastic Neuroepithelial Tumor +

Gangliocytoma +

Ganglioglioma +

Low Grade Glioma +

Low-Grade Neuroepithelial Tumor, NOS +

Neuronal And Mixed Neuronal-Glial Tumors +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.