Location [1]
Synonyms [1]
PRR4, nectin-4, LNIR, EDSS1

PVRL4 is altered in 1.46% of all cancers with bladder urothelial carcinoma, colon adenocarcinoma, melanoma, lung adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

PVRL4 GENIE Cases - Top Diseases

The most common alterations in PVRL4 are PVRL4 Mutation (0.18%), PVRL4 Amplification (0.04%), PVRL4 A117T (0.01%), PVRL4 H241L (0.01%), and PVRL4 K85R (0.01%) [3].

PVRL4 GENIE Cases - Top Alterations

Significance of PVRL4 in Diseases

Bladder Carcinoma +

Urothelial Carcinoma +

Malignant Solid Tumor +

Fallopian Tube Carcinoma +

Malignant Ovarian Epithelial Tumor +

Primary Peritoneal Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.