Overview

Location [1]
1q23.3
Synonyms [1]
PRR4, EDSS1, nectin-4, LNIR

PVRL4 is altered in 1.88% of all cancers with melanoma, lung adenocarcinoma, bladder urothelial carcinoma, colon adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

PVRL4 GENIE Cases - Top Diseases

The most common alterations in PVRL4 are PVRL4 Mutation (1.47%), PVRL4 Amplification (0.31%), PVRL4 H241L (0.08%), PVRL4 K85R (0.06%), and PVRL4 X411_splice (0.04%) [3].

PVRL4 GENIE Cases - Top Alterations

Significance of PVRL4 in Diseases

Malignant Solid Tumor +

Urothelial Carcinoma +

Gastric Carcinoma +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Malignant Ovarian Epithelial Tumor +

Pancreatic Carcinoma +

Bladder Carcinoma +

Ovarian Carcinoma +

Esophageal Carcinoma +

Head And Neck Carcinoma +

Fallopian Tube Carcinoma +

Primary Peritoneal Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.