Overview

Location [1]
6q26
Protein [2]
Protein quaking
Synonyms [1]
QK, hqkI, QK1, QK3, Hqk

QKI, KH domain containing, RNA binding (QKI) is a gene that encodes a protein that functions by binding to RNA and regulating pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. Missense mutations, frameshift deletions, synonymous mutations, and nonsense mutations are observed in cancers such as colon cancer, stomach cancer, and skin cancer.

QKI is altered in 0.50% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, glioblastoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].

QKI GENIE Cases - Top Diseases

The most common alterations in QKI are QKI K134fs (0.26%), QKI-RAF1 Fusion (0.07%), QKI-NTRK2 Fusion (0.07%), QKI Loss (0.05%), and QKI Fusion (0.03%) [3].

QKI GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.