Overview

Location [1]
8q24.11
Protein [2]
Double-strand-break repair protein rad21 homolog
Synonyms [1]
hHR21, CDLS4, HR21, NXP1, MCD1, HRAD21, SCC1

RAD21 homolog (RAD21) is a gene that encodes a protein that functions to repair DNA double-strand breaks. The protein also plays a role in chromatid adhesion during mitosis. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

RAD21 is altered in 2.12% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, prostate adenocarcinoma, colon adenocarcinoma, and invasive breast carcinoma having the greatest prevalence of alterations [3].

RAD21 GENIE Cases - Top Diseases

The most common alterations in RAD21 are RAD21 Amplification (1.32%), RAD21 Mutation (0.92%), RAD21 Loss (0.03%), RAD21 L571F (0.01%), and RAD21 M287V (0.01%) [3].

RAD21 GENIE Cases - Top Alterations

Significance of RAD21 in Diseases

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.