Location [1]
Protein [2]
DNA repair protein RAD52 homolog
Synonyms [1]

RAD52 is altered in 1.24% of all cancers with colon adenocarcinoma, testicular mixed germ cell tumor, breast invasive ductal carcinoma, lung adenocarcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

RAD52 GENIE Cases - Top Diseases

The most common alterations in RAD52 are RAD52 Amplification (0.72%), RAD52 Mutation (0.30%), RAD52 Loss (0.03%), RAD52 E130K (0.01%), and RAD52 G21S (0.01%) [3].

RAD52 GENIE Cases - Top Alterations

Significance of RAD52 in Diseases

Malignant Solid Tumor +

Urothelial Carcinoma +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Mesothelioma +

Small Cell Lung Carcinoma +

Uveal Melanoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.