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Associated Genetic Biomarkers
RAD52 is altered in 1.45% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, testicular mixed germ cell tumor, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in RAD52 are RAD52 Amplification (0.99%), RAD52 Mutation (0.40%), RAD52 Loss (0.04%), RAD52 E130K (0.07%), and RAD52 Fusion (0.07%) .
RAD52 status serves as an inclusion eligibility criteria in 2 clinical trials, of which 1 is open and 1 is closed. Of the trials that contain RAD52 status as an inclusion criterion, 2 are phase 2 (1 open).
Trials with RAD52 status in the inclusion eligibility criteria most commonly target small cell lung carcinoma and urothelial carcinoma .
The most frequent alterations to serve as inclusion eligibility criteria are RAD52 Loss and RAD52 Mutation .
Olaparib is the most frequent therapy in trials with RAD52 as an inclusion criteria .
Significance of RAD52 in Diseases
Small Cell Lung Carcinoma +
RAD52 is altered in 1.43% of small cell lung carcinoma patients .
RAD52 is an inclusion criterion in 1 clinical trial for small cell lung carcinoma, of which 0 are open and 1 is closed. Of the trial that contains RAD52 status and small cell lung carcinoma as inclusion criteria, 1 is phase 2 (0 open) .
Urothelial Carcinoma +
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.