Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
8q22.1
Protein [2]
DNA repair and recombination protein RAD54B
Synonyms [1]
RDH54

RAD54B is altered in 1.99% of all cancers with melanoma, colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, and glioblastoma having the greatest prevalence of alterations [3].

RAD54B GENIE Cases - Top Diseases

The most common alterations in RAD54B are RAD54B Mutation (0.26%), RAD54B Amplification (0.04%), RAD54B G833E (0.01%), RAD54B E638K (0.00%), and RAD54B G84R (0.00%) [3].

RAD54B GENIE Cases - Top Alterations

Significance of RAD54B in Diseases

Melanoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.