Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
5q14.3
Protein [2]
Ras GTPase-activating protein 1
Synonyms [1]
RASA, RASGAP, CM-AVM, PKWS, p120RASGAP, CMAVM, p120GAP, GAP, p120

RASA1 is altered in 0.18% of all cancers with colon adenocarcinoma, prostate adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

RASA1 GENIE Cases - Top Diseases

The most common alterations in RASA1 are RASA1 Loss (0.12%) and RASA1 Amplification (0.01%) [3].

RASA1 GENIE Cases - Top Alterations

Significance of RASA1 in Diseases

Malignant Solid Tumor +

Melanoma +

Non-Small Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.