Biomarkers /

RASA1

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Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
5q14.3
Protein [2]
Ras GTPase-activating protein 1
Synonyms [1]
GAP, RASA, p120RASGAP, PKWS, CMAVM1, RASGAP, CMAVM, CM-AVM, p120, p120GAP

RASA1 is altered in 1.97% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, squamous cell lung carcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

RASA1 GENIE Cases - Top Diseases

The most common alterations in RASA1 are RASA1 Mutation (1.40%), RASA1 Loss (0.15%), RASA1 E429* (0.03%), RASA1 R427Q (0.02%), and RASA1 R1010* (0.02%) [3].

RASA1 GENIE Cases - Top Alterations

Clinical Trials

View Clinical Trials for RASA1

Significance of RASA1 in Diseases

Non-Small Cell Lung Carcinoma +

Melanoma +

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.