Overview

Location [1]
18q11.2
Protein [2]
DNA endonuclease RBBP8
Synonyms [1]
COM1, CTIP, RIM, SAE2, JWDS, SCKL2

RBBP8 is altered in 2.56% of all cancers with colon adenocarcinoma, lung adenocarcinoma, melanoma, glioblastoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

RBBP8 GENIE Cases - Top Diseases

The most common alterations in RBBP8 are RBBP8 Mutation (0.35%), RBBP8 Amplification (0.03%), RBBP8 K357Nfs*3 (0.03%), RBBP8 V329I (0.01%), and RBBP8 H358Tfs*8 (0.01%) [3].

RBBP8 GENIE Cases - Top Alterations

Significance of RBBP8 in Diseases

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.