Overview

RNA binding motif protein 15 (RBM15) is a gene that encodes a protein that functions as a repressor in several cell signaling pathways. The protein may also bind to RNA via interaction with the spliceosome. Fusions, missense mutations, and silent mutations are observed in cancers such as ovarian cancer.

RBM15 is altered in 1.85% of all cancers with breast invasive ductal carcinoma, high grade ovarian serous adenocarcinoma, lung adenocarcinoma, sebaceous carcinoma, and adenocarcinoma of unknown primary having the greatest prevalence of alterations [3].

The most common alterations in RBM15 are RBM15 A4T (0.26%), RBM15 A876T (0.85%), RBM15 D7N (0.22%), RBM15 F358C (0.22%), and RBM15 G620C (1.85%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.