Overview

Location [1]
3q27.3
Protein [2]
Replication factor C subunit 4
Synonyms [1]
RFC37, A1

RFC4 is altered in 0.01% of all cancers with lung adenocarcinoma and squamous cell lung carcinoma having the greatest prevalence of alterations [3].

RFC4 GENIE Cases - Top Diseases

The most common alteration in RFC4 is RFC4-EIF4A2 Fusion (0.01%) [3].

RFC4 GENIE Cases - Top Alterations

Significance of RFC4 in Diseases

Adenocarcinoma Of The Gastroesophageal Junction +

Bile Duct Carcinoma +

Bladder Carcinoma +

Breast Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Colorectal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Carcinoma +

Lung Carcinoma +

Malignant Solid Tumor +

Malignant Uterine Neoplasm +

Melanoma +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Soft Tissue Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.