Overview

Location [1]
3p21.31
Protein [2]
Transforming protein RhoA
Synonyms [1]
ARHA, RHOH12, ARH12, EDFAOB, RHO12

Ras homolog family member A (RHOA) is a gene that encodes a protein that functions in the regulation of a cell signaling pathway that links plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as esophageal cancer, intestinal cancer, and stomach cancer.

RHOA is altered in 0.96% of all cancers with bladder urothelial carcinoma, colon adenocarcinoma, gastric adenocarcinoma, breast invasive lobular carcinoma, and angioimmunoblastic T-cell lymphoma having the greatest prevalence of alterations [3].

RHOA GENIE Cases - Top Diseases

The most common alterations in RHOA are RHOA Mutation (0.85%), RHOA G17V (0.09%), RHOA Loss (0.09%), RHOA G17E (0.10%), and RHOA Y42C (0.05%) [3].

RHOA GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.