Overview

Location [1]
17q11.2
Protein [2]
Mitochondrial Rho GTPase 1
Synonyms [1]
MIRO-1, ARHT1, MIRO1

RHOT1 is altered in 0.23% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

RHOT1 GENIE Cases - Top Diseases

The most common alterations in RHOT1 are RHOT1 Amplification (0.11%), RHOT1 R618* (0.03%), RHOT1 V84I (0.03%), RHOT1 Fusion (0.03%), and RHOT1 I42F (0.09%) [3].

RHOT1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.