Location [1]
Protein [2]
Rapamycin-insensitive companion of mTOR
Synonyms [1]

RPTOR independent companion of MTOR, complex 2 (RICTOR) is a gene that encodes the protein RICTOR (rapamycin-insensitive companion of mTOR). RICTOR is a member of the protein complex mTORC2 that functions in the regulation of actin organization, cell proliferation and survival. Missense mutations, nonsense mutations, silent mutations, amplifications, and frameshift deletions and insertions have been observed in cancers such as breast cancer, endometrial cancer, intestinal cancer, lung cancer, and stomach cancer.

RICTOR is altered in 2.35% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, bladder urothelial carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

RICTOR GENIE Cases - Top Diseases

The most common alterations in RICTOR are RICTOR Mutation (1.69%), RICTOR Amplification (0.68%), RICTOR S1101L (0.03%), RICTOR S1284L (0.02%), and RICTOR Loss (0.02%) [3].

RICTOR GENIE Cases - Top Alterations

Significance of RICTOR in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Colorectal Carcinoma +

Non-Small Cell Lung Carcinoma +

Hepatocellular Carcinoma +

Non-Hodgkin Lymphoma +

Small Cell Lung Carcinoma +

Melanoma +

Squamous Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Pancreatic Carcinoma +

Renal Cell Carcinoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Gastric Carcinoma +

Gastric Adenocarcinoma +

Neuroendocrine Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

Cancer +

Ovarian Carcinoma +

Liposarcoma +

Peritoneal Mesothelioma +

Chondrosarcoma +

Prostate Carcinoma +

Biliary Tract Neoplasm +

Hematologic And Lymphocytic Disorder +

Osteosarcoma +

Sarcoma +

Hematopoietic And Lymphoid Malignancy +

Thyroid Gland Carcinoma +

Hematopoietic And Lymphoid System Neoplasm +

Myeloid Neoplasm +

Aggressive Systemic Mastocytosis +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Ewing Sarcoma +

Histiocytic And Dendritic Cell Neoplasm +

Mast Cell Leukemia +

Myelodysplastic Syndromes +

Pecoma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.