Overview

Location [1]
5p13.1
Pathway
PI3K/AKT1/MTOR
Protein [2]
Rapamycin-insensitive companion of mTOR
Synonyms [1]
AVO3, PIA, hAVO3

RPTOR independent companion of MTOR, complex 2 (RICTOR) is a gene that encodes the protein RICTOR (rapamycin-insensitive companion of mTOR). RICTOR is a member of the protein complex mTORC2 that functions in the regulation of actin organization, cell proliferation and survival. Missense mutations, nonsense mutations, silent mutations, amplifications, and frameshift deletions and insertions have been observed in cancers such as breast cancer, endometrial cancer, intestinal cancer, lung cancer, and stomach cancer.

RICTOR is altered in 2.08% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, bladder urothelial carcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

RICTOR GENIE Cases - Top Diseases

The most common alterations in RICTOR are RICTOR Mutation (1.31%), RICTOR Mutation (somatic) (1.31%), RICTOR Amplification (0.56%), RICTOR S1101L (0.02%), and RICTOR N941S (0.01%) [3].

RICTOR GENIE Cases - Top Alterations

Significance of RICTOR in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Squamous Cell Lung Carcinoma +

Non-Small Cell Lung Carcinoma +

Pancreatic Carcinoma +

Hepatocellular Carcinoma +

Small Cell Lung Carcinoma +

Endometrial Carcinoma +

Melanoma +

Neuroendocrine Carcinoma +

Glioblastoma +

Cancer +

Gastric Carcinoma +

Gastric Adenocarcinoma +

Ovarian Carcinoma +

Biliary Tract Neoplasm +

Prostate Carcinoma +

Sarcoma +

Head And Neck Squamous Cell Carcinoma +

Hematopoietic And Lymphoid Malignancy +

Histiocytic And Dendritic Cell Neoplasm +

Peritoneal Mesothelioma +

Renal Cell Carcinoma +

Thyroid Gland Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.