Overview

Location [1]
5p13.1
Pathway
PI3K/AKT1/MTOR
Synonyms [1]
PIA, hAVO3, AVO3

RPTOR independent companion of MTOR, complex 2 (RICTOR) is a gene that encodes the protein RICTOR (rapamycin-insensitive companion of mTOR). RICTOR is a member of the protein complex mTORC2 that functions in the regulation of actin organization, cell proliferation and survival. Missense mutations, nonsense mutations, silent mutations, amplifications, and frameshift deletions and insertions have been observed in cancers such as breast cancer, endometrial cancer, intestinal cancer, lung cancer, and stomach cancer.

Significance of RICTOR in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Colorectal Carcinoma +

Hepatocellular Carcinoma +

Non-Hodgkin Lymphoma +

Non-Small Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Melanoma +

Pancreatic Carcinoma +

Renal Cell Carcinoma +

Small Cell Lung Carcinoma +

Squamous Cell Lung Carcinoma +

Aggressive Systemic Mastocytosis +

Biliary Tract Neoplasm +

Cancer +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Endometrial Carcinoma +

Ewing Sarcoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Liposarcoma +

Mast Cell Leukemia +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Neuroendocrine Carcinoma +

Osteosarcoma +

Ovarian Carcinoma +

Pecoma +

Peritoneal Mesothelioma +

Prostate Carcinoma +

Sarcoma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thyroid Gland Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.