Overview

Location [1]
5p13.1
Pathway
PI3K/AKT1/MTOR
Protein [2]
Rapamycin-insensitive companion of mTOR
Synonyms [1]
AVO3, PIA, hAVO3

RPTOR independent companion of MTOR, complex 2 (RICTOR) is a gene that encodes the protein RICTOR (rapamycin-insensitive companion of mTOR). RICTOR is a member of the protein complex mTORC2 that functions in the regulation of actin organization, cell proliferation and survival. Missense mutations, nonsense mutations, silent mutations, amplifications, and frameshift deletions and insertions have been observed in cancers such as breast cancer, endometrial cancer, intestinal cancer, lung cancer, and stomach cancer.

RICTOR is altered in 2.08% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, bladder urothelial carcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

RICTOR GENIE Cases - Top Diseases

The most common alterations in RICTOR are RICTOR Mutation (1.31%), RICTOR Amplification (0.56%), RICTOR S1101L (0.02%), RICTOR N941S (0.01%), and RICTOR R336H (0.01%) [3].

RICTOR GENIE Cases - Top Alterations

Significance of RICTOR in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Non-Small Cell Lung Carcinoma +

Hepatocellular Carcinoma +

Small Cell Lung Carcinoma +

Melanoma +

Squamous Cell Lung Carcinoma +

Pancreatic Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Renal Cell Carcinoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Neuroendocrine Carcinoma +

Glioblastoma +

Cancer +

Gastric Carcinoma +

Gastric Adenocarcinoma +

Ovarian Carcinoma +

Biliary Tract Neoplasm +

Prostate Carcinoma +

Sarcoma +

Aggressive Systemic Mastocytosis +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Ewing Sarcoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Liposarcoma +

Mast Cell Leukemia +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Osteosarcoma +

Pecoma +

Peritoneal Mesothelioma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thyroid Gland Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.