Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
1q22
Synonyms [1]
ROC1, NS8, RIT, RIBB

Ras-like without CAAX 1 (RIT1) is a gene that encodes a protein that belongs to the Ras-related GTPases subfamily. The protein regulates p38 MAPK-dependent signaling cascades that are related to cellular stress. Missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as intestinal cancer, lung cancer, and salivary gland cancer.

Significance of RIT1 in Diseases

Acute Myeloid Leukemia +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Chronic Myelomonocytic Leukemia +

Myelodysplastic Syndromes +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Secondary Acute Myeloid Leukemia +

Therapy-Related Acute Myeloid Leukemia +

Therapy-Related Myelodysplastic Syndrome +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.