Overview

Location [1]
1q22
Protein [2]
GTP-binding protein Rit1
Synonyms [1]
NS8, RIBB, RIT, ROC1

Ras-like without CAAX 1 (RIT1) is a gene that encodes a protein that belongs to the Ras-related GTPases subfamily. The protein regulates p38 MAPK-dependent signaling cascades that are related to cellular stress. Missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as intestinal cancer, lung cancer, and salivary gland cancer.

RIT1 is altered in 1.01% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, colon adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

RIT1 GENIE Cases - Top Diseases

The most common alterations in RIT1 are RIT1 Amplification (0.52%), RIT1 Mutation (0.34%), RIT1 M90I (0.04%), RIT1 M90V (0.01%), and RIT1 A77T (0.01%) [3].

RIT1 GENIE Cases - Top Alterations

Significance of RIT1 in Diseases

Acute Myeloid Leukemia +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Chronic Myelomonocytic Leukemia +

Myelodysplastic Syndromes +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Secondary Acute Myeloid Leukemia +

Therapy-Related Acute Myeloid Leukemia +

Therapy-Related Myelodysplastic Syndrome +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.