Location [1]
Protein [2]
Replication protein A 70 kDa DNA-binding subunit, N-terminally processed
Synonyms [1]

RPA1 is altered in 0.83% of all cancers with colon adenocarcinoma, lung adenocarcinoma, melanoma, and glioblastoma having the greatest prevalence of alterations [3].

RPA1 GENIE Cases - Top Diseases

The most common alterations in RPA1 are RPA1 Mutation (0.16%), RPA1 E68K (0.01%), RPA1 F245L (0.00%), RPA1 G387S (0.00%), and RPA1 T303M (0.00%) [3].

RPA1 GENIE Cases - Top Alterations

Significance of RPA1 in Diseases

Malignant Solid Tumor +

Malignant Uterine Neoplasm +

Melanoma +

Colorectal Carcinoma +

Lung Carcinoma +

Non-Small Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Bile Duct Carcinoma +

Bladder Carcinoma +

Breast Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Carcinoma +

Mesothelioma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Small Cell Lung Carcinoma +

Squamous Cell Lung Carcinoma +

Uveal Melanoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.