Overview

Location [1]
17p13.3
Protein [2]
Replication protein A 70 kDa DNA-binding subunit, N-terminally processed
Synonyms [1]
RP-A, MST075, REPA1, RPA70, HSSB, RF-A

RPA1 is altered in 1.35% of all cancers with lung adenocarcinoma, colon adenocarcinoma, melanoma, glioblastoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

RPA1 GENIE Cases - Top Diseases

The most common alterations in RPA1 are RPA1 Mutation (1.25%), RPA1 Fusion (0.04%), RPA1 Y409C (0.04%), RPA1 E68K (0.05%), and RPA1 F245L (0.05%) [3].

RPA1 GENIE Cases - Top Alterations

Significance of RPA1 in Diseases

Malignant Solid Tumor +

Gallbladder Carcinoma +

Melanoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Malignant Uterine Neoplasm +

Small Cell Lung Carcinoma +

Lung Carcinoma +

Colorectal Carcinoma +

Non-Small Cell Lung Carcinoma +

Cervical Carcinoma +

Bladder Carcinoma +

Breast Carcinoma +

Clear Cell Renal Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Head And Neck Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Bile Duct Carcinoma +

Bronchogenic Carcinoma +

Cholangiocarcinoma +

Esophageal Squamous Cell Carcinoma +

Gastric Adenocarcinoma +

Mesothelioma +

Soft Tissue Sarcoma +

Uveal Melanoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.