Biomarkers /

RPS6KB2

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Overview

Location [1]
11q13.2
Protein [2]
Ribosomal protein S6 kinase beta-2
Synonyms [1]
SRK, S6K-beta2, P70-beta-2, S6KB, S6Kbeta, P70-beta, S6KI(2), S6K2, P70-beta-1, KLS, p70S6Kb, STK14B, p70(S6K)-beta

RPS6KB2 is altered in 1.72% of all cancers with breast invasive ductal carcinoma, invasive breast carcinoma, colon adenocarcinoma, lung adenocarcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

RPS6KB2 GENIE Cases - Top Diseases

The most common alterations in RPS6KB2 are RPS6KB2 Amplification (1.08%), RPS6KB2 Mutation (0.46%), RPS6KB2 Loss (0.08%), RPS6KB2 D335N (0.01%), and RPS6KB2 D354N (0.01%) [3].

RPS6KB2 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.