Biomarkers /

RXRA

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Overview

Location [1]
9q34.2
Protein [2]
Retinoic acid receptor RXR-alpha
Synonyms [1]
NR2B1

RXRA is altered in 1.10% of all cancers with bladder urothelial carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and lung adenocarcinoma having the greatest prevalence of alterations [3].

RXRA GENIE Cases - Top Diseases

The most common alterations in RXRA are RXRA S427F (0.12%), RXRA Loss (0.10%), RXRA L111fs (0.08%), RXRA Amplification (0.05%), and RXRA A344T (0.03%) [3].

RXRA GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.