Biomarkers /
S1PR2
Overview
Sphingosine-1-phosphate receptor 2 (S1PR2) is a gene that encodes a protein that functions as a G-protein coupled receptor. The protein is important for sphingosine 1-phosphate-induced cell proliferation, survival and transcriptional activation. Missense mutations, nonsense mutations, silent mutations, nonstop extensions, frameshift insertions, and in-frame deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.
S1PR2 is altered in 0.16% of all cancers with colon adenocarcinoma, melanoma, anaplastic astrocytoma, atypical fibroxanthoma, and cancer, NOS having the greatest prevalence of alterations [3].
The most common alterations in S1PR2 are S1PR2 A187T (0.08%), S1PR2 E177K (0.08%), S1PR2 G153E (1.09%), S1PR2 H189D (1.09%), and S1PR2 I287T (0.08%) [3].
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.