Overview

Location [1]
5p15.33
Protein [2]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Synonyms [1]
SDHF, SDH1, FP, CMD1GG, SDH2, PGL5

Succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA) is a gene that encodes a catalytic protein that is a member of succinate-ubiquinone oxidoreductase. The complex participates in the mitochondrial respiratory chain. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

SDHA is altered in 1.97% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, bladder urothelial carcinoma, and squamous cell lung carcinoma having the greatest prevalence of alterations [3].

SDHA GENIE Cases - Top Diseases

The most common alterations in SDHA are SDHA Mutation (1.02%), SDHA Amplification (1.01%), SDHA Loss (0.05%), SDHA L639V (0.03%), and SDHA R352Q (0.02%) [3].

SDHA GENIE Cases - Top Alterations

Significance of SDHA in Diseases

Gastrointestinal Stromal Tumor +

Renal Cell Carcinoma +

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Leiomyosarcoma +

Clear Cell Renal Cell Carcinoma +

Breast Carcinoma +

Hereditary Leiomyomatosis And Renal Cell Cancer +

Osteosarcoma +

Papillary Renal Cell Carcinoma +

Paraganglioma +

Peritoneal Mesothelioma +

Pleural Mesothelioma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.