Overview

Location [1]
1p36.13
Protein [2]
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Synonyms [1]
SDH1, IP, SDH, CWS2, PGL4, SDH2, SDHIP

Succinate dehydrogenase complex, subunit B, iron sulfur (lp) (SDHB) is a gene that encodes a protein that functions as Complex II of the mitochondrial respiratory chain. The protein carries electrons from FADH to CoQ to oxidize succinate. Missense, nonsense, and silent mutations are observed in cancers such as lung cancer, skin cancer, and stomach cancer.

SDHB is altered in 0.43% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

SDHB GENIE Cases - Top Diseases

The most common alterations in SDHB are SDHB Mutation (0.43%), SDHB Loss (0.04%), SDHB Amplification (0.03%), SDHB Y147C (0.02%), and SDHB R46Q (0.01%) [3].

SDHB GENIE Cases - Top Alterations

Significance of SDHB in Diseases

Renal Cell Carcinoma +

Gastrointestinal Stromal Tumor +

Malignant Solid Tumor +

Papillary Renal Cell Carcinoma +

Paraganglioma +

Clear Cell Renal Cell Carcinoma +

Non-Small Cell Lung Carcinoma +

Breast Carcinoma +

Adrenal Gland Pheochromocytoma +

Chromophobe Renal Cell Carcinoma +

Hereditary Leiomyomatosis And Renal Cell Cancer +

Leiomyosarcoma +

Non-Clear Cell Renal Cell Carcinoma +

Osteosarcoma +

Peritoneal Mesothelioma +

Pleural Mesothelioma +

Sarcomatoid Renal Cell Carcinoma +

Unclassified Renal Cell Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.