Location [1]
Protein [2]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Synonyms [1]

Succinate dehydrogenase complex, subunit C, integral membrane protein (SDHC) is a gene that encodes a protein that is a component of succinate dehydrogenase. The protein anchors other proteins of the complex to the inner mitochondrial membrane. Missense and silent mutations are observed in cancers such as biliary tract cancer, ovarian cancer, and pancreatic cancer.

SDHC is altered in 1.50% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, pancreatic adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

SDHC GENIE Cases - Top Diseases

The most common alterations in SDHC are SDHC Mutation (0.88%), SDHC V103L (34.28%), SDHC Y99N (34.03%), SDHC Amplification (0.63%), and SDHC Nonsense (0.71%) [3].

SDHC GENIE Cases - Top Alterations

Significance of SDHC in Diseases

Gastrointestinal Stromal Tumor +

Renal Cell Carcinoma +

Malignant Solid Tumor +

Paraganglioma +

Osteosarcoma +

Sarcoma +

Leiomyosarcoma +

Non-Small Cell Lung Carcinoma +

Breast Carcinoma +

Clear Cell Renal Cell Carcinoma +

Adrenal Gland Pheochromocytoma +

Hereditary Leiomyomatosis And Renal Cell Cancer +

Papillary Renal Cell Carcinoma +

Peritoneal Mesothelioma +

Pleural Mesothelioma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.