Overview

Location [1]
1q23.3
Protein [2]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Synonyms [1]
QPS1, CYB560, CYBL, SDH3, PGL3

Succinate dehydrogenase complex, subunit C, integral membrane protein (SDHC) is a gene that encodes a protein that is a component of succinate dehydrogenase. The protein anchors other proteins of the complex to the inner mitochondrial membrane. Missense and silent mutations are observed in cancers such as biliary tract cancer, ovarian cancer, and pancreatic cancer.

SDHC is altered in 0.77% of all cancers with breast invasive ductal carcinoma, bladder urothelial carcinoma, lung adenocarcinoma, invasive breast carcinoma, and dedifferentiated liposarcoma having the greatest prevalence of alterations [3].

SDHC GENIE Cases - Top Diseases

The most common alterations in SDHC are SDHC Amplification (0.59%), SDHC Mutation (0.27%), SDHC R133* (0.02%), SDHC T33M (0.01%), and SDHC L5F (0.01%) [3].

SDHC GENIE Cases - Top Alterations

Significance of SDHC in Diseases

Gastrointestinal Stromal Tumor +

Renal Cell Carcinoma +

Malignant Solid Tumor +

Paraganglioma +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Adrenal Gland Pheochromocytoma +

Clear Cell Renal Cell Carcinoma +

Hereditary Leiomyomatosis And Renal Cell Cancer +

Leiomyosarcoma +

Osteosarcoma +

Papillary Renal Cell Carcinoma +

Peritoneal Mesothelioma +

Pleural Mesothelioma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.