Overview

Location [1]
1q23.3
Synonyms [1]
CYBL, QPS1, SDH3, CYB560, PGL3

Succinate dehydrogenase complex, subunit C, integral membrane protein (SDHC) is a gene that encodes a protein that is a component of succinate dehydrogenase. The protein anchors other proteins of the complex to the inner mitochondrial membrane. Missense and silent mutations are observed in cancers such as biliary tract cancer, ovarian cancer, and pancreatic cancer.

Significance of SDHC in Diseases

Gastrointestinal Stromal Tumor +

Renal Cell Carcinoma +

Malignant Solid Tumor +

Paraganglioma +

Adrenal Gland Pheochromocytoma +

Breast Carcinoma +

Clear Cell Renal Cell Carcinoma +

Hereditary Leiomyomatosis And Renal Cell Cancer +

Leiomyosarcoma +

Non-Small Cell Lung Carcinoma +

Osteosarcoma +

Papillary Renal Cell Carcinoma +

Peritoneal Mesothelioma +

Pleural Mesothelioma +

Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.