Biomarkers /
SEC31A
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Associated Diseases
Overview
SEC31 homolog A (SEC31A) is a gene that encodes a protein that functions in vesicle budding from the endoplasmic reticulum (ER). The protein may also be involved in ER-Golgi transport. Fusions and missense mutations are observed in cancers such as breast cancer.
SEC31A is altered in 0.08% of all cancers with lung adenocarcinoma, acute myeloid leukemia, cancer of unknown primary, diffuse large B-cell lymphoma, not otherwise specified, and glioblastoma having the greatest prevalence of alterations [3].
The most common alteration in SEC31A is SEC31A-ALK Fusion (0.08%) [3].
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.