Serum/glucocorticoid regulated kinase 1 (SGK1) is a gene that encodes a protein that functions as a serine/threonine kinase. The protein is involved in the cellular stress response by activating potassium, sodium, and chloride ion channels. In doing so, the protein aids in cell survival, neuronal excitability, and renal sodium excretion. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, kidney cancer, and skin cancer.
SGK1 is altered in 0.29% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, follicular lymphoma, B-cell lymphoblastic leukemia/lymphoma, acute myeloid leukemia, and mature B-cell neoplasm having the greatest prevalence of alterations .
The most common alterations in SGK1 are SGK1 Mutation (1.07%), SGK1 Loss (0.22%), SGK1 A26V (0.14%), SGK1 X51_splice (0.12%), and SGK1 A26G (0.09%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.