Overview

Soc-2 suppressor of clear homolog (SHOC2) is a gene that encodes a protein that functions in the RAS/ERK MAP kinase signaling pathway as a scaffold linking Ras to downstream signal transducers. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

SHOC2 is altered in 0.72% of all cancers with lung adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, colon adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

The most common alterations in SHOC2 are SHOC2 Loss (0.11%), SHOC2 Amplification (0.05%), SHOC2 R579H (0.01%), SHOC2 D69G (0.01%), and SHOC2 E8* (0.01%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.