Structural maintenance of chromosomes 1A (SMC1A) is a gene that encodes a protein that functions as an integral component of functional kinetochores. The protein is also suspected to play a role in DNA repair. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.
Modified: July 1, 2015
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