Suppressor of cytokine signaling 1 (SOCS1) is a gene that encodes a protein that functions as a cytokine-inducible negative regulator of cytokine signaling. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions and insertions are observed in cancers such as hematopoietic and lymphoid cancers, intestinal cancer, and lung cancer.
SOCS1 is altered in 0.87% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, lung adenocarcinoma, follicular lymphoma, breast invasive ductal carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in SOCS1 are SOCS1 Amplification (0.21%), SOCS1 Loss (0.05%), SOCS1 Fusion (0.10%), SOCS1 A49_P50del (0.06%), and SOCS1 M1? (0.02%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.