Location [1]
Protein [2]
Son of sevenless homolog 1
Synonyms [1]

Son of sevenless homolog 1 (SOS1) is a gene that encodes a protein that functions as a guanine nucleotide exchange factor for Ras proteins. The protein regulates RAS proteins by mediating the exchange of GTP to GDP. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

SOS1 is altered in 1.78% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

SOS1 GENIE Cases - Top Diseases

The most common alterations in SOS1 are SOS1 Mutation (1.59%), SOS1 N233Y (0.06%), SOS1 Amplification (0.04%), SOS1 Loss (0.03%), and SOS1 M269K (0.02%) [3].

SOS1 GENIE Cases - Top Alterations

Significance of SOS1 in Diseases

Melanoma +

Ganglioglioma +

Astrocytic Tumor +

Diffuse Glioma +

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Neuronal And Mixed Neuronal-Glial Tumors +

Pilocytic Astrocytoma +

Low Grade Glioma +

Dysembryoplastic Neuroepithelial Tumor +

Gangliocytoma +

Low-Grade Neuroepithelial Tumor, NOS +

Pilomyxoid Astrocytoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.