Associated Genetic Biomarkers
Son of sevenless homolog 1 (SOS1) is a gene that encodes a protein that functions as a guanine nucleotide exchange factor for Ras proteins. The protein regulates RAS proteins by mediating the exchange of GTP to GDP. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.
SOS1 is altered in 0.07% of all cancers.
The most common alterations in SOS1 are SOS1 Amplification (0.02%) and SOS1 Loss (0.02%) .
SOS1 status serves as an inclusion eligibility criteria in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains SOS1 status as an inclusion criterion, 1 is phase 1 (1 open).
Trials with SOS1 status in the inclusion eligibility criteria most commonly target malignant solid tumor .
The most frequent alteration to serve as an inclusion eligibility criterion is SOS1 Mutation .
Jsi-1187 is the most frequent therapy in trials with SOS1 as an inclusion criteria .
Significance of SOS1 in Diseases
Malignant Solid Tumor +
SOS1 is an inclusion criterion in 1 clinical trial for melanoma, of which 1 is open and 0 are closed. Of the trial that contains SOS1 status and melanoma as inclusion criteria, 1 is phase 1 (1 open) .
Non-Small Cell Lung Carcinoma +
SOS1 is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains SOS1 status and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.