Location [1]
Protein [2]
Son of sevenless homolog 1
Synonyms [1]

Son of sevenless homolog 1 (SOS1) is a gene that encodes a protein that functions as a guanine nucleotide exchange factor for Ras proteins. The protein regulates RAS proteins by mediating the exchange of GTP to GDP. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

SOS1 is altered in 0.07% of all cancers.

The most common alterations in SOS1 are SOS1 Amplification (0.02%) and SOS1 Loss (0.02%) [3].

SOS1 GENIE Cases - Top Alterations

Significance of SOS1 in Diseases

Malignant Solid Tumor +

Melanoma +

Non-Small Cell Lung Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.