SPEN family transcriptional repressor (SPEN) is a gene that encodes a hormone inducible transcriptional repressor protein that regulates transcription. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.
SPEN is altered in 3.82% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations .
The most common alterations in SPEN are SPEN Loss (0.07%), SPEN Amplification (0.05%), SPEN A2105fs (0.04%), SPEN I1052fs (0.03%), and SPEN S2900L (0.03%) .
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3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.