Location [1]
Protein [2]
Msx2-interacting protein
Synonyms [1]

SPEN family transcriptional repressor (SPEN) is a gene that encodes a hormone inducible transcriptional repressor protein that regulates transcription. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

SPEN is altered in 3.82% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

SPEN GENIE Cases - Top Diseases

The most common alterations in SPEN are SPEN Loss (0.07%), SPEN Amplification (0.05%), SPEN A2105fs (0.04%), SPEN I1052fs (0.03%), and SPEN S2900L (0.03%) [3].

SPEN GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.